New Step by Step Map For cees dekker

‘Indeed, that may be about proper. I try to find a Bodily idea of Organic techniques in a very bottom-up way. I believe you could possibly distinguish three lines of investigation in my team in the mean time. The 1st concerns chromosome construction: How will you receive a metre-lengthy DNA polymer folded and organised in this type of microscopic mobile? We have created visualisation tactics that make it possible for us to check how, as an example, SMC proteins loop DNA (video clip on Youtube) in an effort to Establish up chromosomes.

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, Groningen scientists existing the effects in their endeavours to help make labs more sustainable and supply strategies for other labs. 

Regrettably, For some time after Iijima’s report, the production of thoroughly clean nanotubes was cumbersome. In 1996, even so, the group of Richard Smalley at Rice University managed to create solitary-walled carbon nanotubes at significant generate. Soon immediately after, I contacted Smalley, and we made a decision to sign up for forces to evaluate the transportation via a solitary carbon nanotube.

2012, discovery that nucleoid occlusion underlies the accuracy of bacterial cell division; and initially at any time study in the dynamics DNA supercoils and the invention of supercoil hopping

Microbiology has only been around for any century, due to the fact we began to review micro-organisms much more critically. I thought nanobiology was an proper phrase, due to the fact all molecular biological appropriate interactions happen with the nanoscale: a protein is a number of nanometres in dimensions, DNA is two nm thick.’

Numerous associated developments followed, exactly where our group set up distinct transistor variants for example solitary-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled a number of transistors into modest evidence-of-theory electronic circuits.

Dynamic ParB–DNA interactions initiate and keep a partition condensate for bacterial chromosome segregation

Let's say, instead of working with regular leading-down silicon electronics, transistors can be created from the bottom up working with single organic and natural molecules because the switching features? This idea, which turned the basis of currently’s area of molecular electronics, initially emerged inside the nineteen seventies.

There was https://www.ceesdekker.net one issue even though — we did not observe any measurable electrical conduction from The only polymer molecules. We concluded that at the single-molecule degree, conducting polymers have been in fact not these terrific conductors, which was alternatively disappointing. We thus broadened our see to try to find much more promising molecules.

FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial mobile division

Later on we spoke once again briefly simply because Dekker felt that our dialogue of his religion immediately grew to become purely philosophical, Whilst it also concretely allows him in his do the job.

2008, first observation of protein-coated DNA translocation through nanopores; resolved the origin in the electrophoretic pressure on DNA in nanopores; identified an important velocity improve of microtubules in electrical fields; learned an anomalous electro-hydrodynamic orientation of microtubules; and fixed the origin of noise in carbon nanotubes in liquid

Case in point (2) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim in the pore is highlighted in pink, plus a 3D rendering of the movement of the DNA rod is shown.